#Lissencephaly is a disorder of neural migration which leads to abnormal folding of the #brain. It translates to “smooth brain” and is a mostly genetic disorder. Children with lissencephaly often have #seizures and #developmentaldelay. It is typically diagnosed and treated by pediatric neurologists. #neurology

A 6-month-old baby boy was referred to a pediatric neurology clinic in Brazil for evaluation of developmental delay. At the beginning of the second trimester, the baby’s mother had had a rash. At birth, the baby had microcephaly. He subsequently developed severe developmental delay and epilepsy. Prenatal ultrasonography at 12 weeks’ gestation and at 29 weeks’ gestation are shown. What is the underlying etiology? Submit your answer or see how others responded: https://nej.md/IC12182025 #MedTok #N

Image Challenge — December 18, 2025