Buffalo vs lion attack Sometimes, lions can find themselves under pressure when the animals they prey on turn the tables and refuse to go down without a fight. While African buffalos are frequent prey for lions, they're formidable opponents in their own right. Armed with two massive horns, the African buffalo has few other predators and is known for its ability to be aggressive. When lions hunt buffalo, they tend to rely on the strength of a group, as the power of a full-grown African buffalo ca