Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

NFL Week 12 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and Arizona Cardinals.

The Arizona Cardinals have 18 players on various injured lists, the most in the NFL. The issue is especially notable with their recent draft picks.

The Arizona Cardinals quarterback, who is filling in for the injured Kyler Murray, completed 47 of his 57 pass attempts, setting a new record for completions in a single game. Drew Bledsoe had 45 completions in 1994, and Jared Goff had the same mark in 2019.

With the activation of linebacker BJ Ojulari from PUP Saturday and the addition of linebacker Mack Wilson Sr. to IR, the Cardinals now have 13 players placed on IR since the cut to 53, three on IR prior to the cut to 53 and one, cornerback Sean Murphy-Bunting, on reserve/non-football injury, also done prior to the reduction to 53.

ARIZONA -- Arizona Cardinals TE Trey McBride was flagged for an unsportsmanlike conduct penalty in their Week 11 loss to the San Francisco 49ers, a penalty that drew plenty of criticism online and around the football world. The flag came after McBride celebrated a first down.

The Arizona Cardinals were not the NFL's most talented team during the second year of coach Jonathan Gannon's tenure, but they were among the most disciplined, committing the league's second-fewest penalties in 2024.