ARIZONA -- The Arizona Cardinals are no strangers to adjusting to opposing fans at State Farm Stadium, though the San Francisco 49ers tend to travel among the best in the NFL in terms of away support.

After another inept defensive performance and a hallow offensive output, the Arizona Cardinals sit at 3-7 and now host the Jacksonville Jaguars on Sunday. The Jaguars only open as small favorites, so things are not completely off the rails yet.

The Arizona Cardinals are searching for answers after a second straight embarrassing loss to an NFC West rival.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The Arizona Cardinals thankfully concluded their practice week on Friday in preparation for Sunday’s game against the San Francisco 49ers. Afterward, the team distributed a massive injury report that lists seven players out and six questionable.

With the activation of linebacker BJ Ojulari from PUP Saturday and the addition of linebacker Mack Wilson Sr. to IR, the Cardinals now have 13 players placed on IR since the cut to 53, three on IR prior to the cut to 53 and one, cornerback Sean Murphy-Bunting, on reserve/non-football injury, also done prior to the reduction to 53.

Bam Knight is active for the Arizona Cardinals' Week 11 game against the San Francisco 49ers and will likely lead the backfield, as he has recently.

Walter Nolen III, a defensive tackle out of Ole Miss, was scouted by the 49ers, who instead took Mykel Williams with the No. 11 pick in the first round. Nolen went to the Cardinals at No. 16 and didn’t make his debut until two weeks ago because of a late-July calf injury.

ARIZONA -- Arizona Cardinals TE Trey McBride was flagged for an unsportsmanlike conduct penalty in their Week 11 loss to the San Francisco 49ers, a penalty that drew plenty of criticism online and around the football world. The flag came after McBride celebrated a first down.