C&EN

Nanopuerarin Improves Doxorubicin Therapeutic Efficacy by Inhibiting Angiogenesis via Regulating NSUN2 in Hepatocellular Carcinoma

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. In this study, aluminum nanopuerarin (nanoPue) particles were ...
ascopubs.org

Development of a Machine Learning Model for Aspyre Lung Blood: A New Assay for Rapid Detection of Actionable Variants From Plasma in Patients With Non–Small Cell Lung Cancer

Development and Validation of an Ipsilateral Breast Tumor Recurrence Risk Estimation Tool Incorporating Real-World Data and Evidence From Meta-Analyses: A Retrospective Multicenter Cohort Study Data ...
C&EN

Hyaluronic Acid Microparticles Promote Uniform Differentiation and Survival of Stem Cells in Spheroid Cultures

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Three-dimensional (3D) cell culture systems have emerged as a ...
STAT

The end of animal testing? Transitioning to models is promising — but no silver bullet

The U.S. Food and Drug Administration’s recently published Roadmap to Reducing Animal Testing in Preclinical Safety Studies may have caused a stir across the pharmaceutical and biotech industries, but ...
Benzinga.com

Mesoblast Targets Accelerated FDA Approval For Heart Failure Drug Revascor

On Monday, Mesoblast Ltd. (NASDAQ:MESO) announced alignment with the U.S. Food and Drug Administration (FDA) on items required for filing a Biologics License Application (BLA) for Revascor ...
GEN

Potency Assays in Cell and Gene Therapy: Strategies for Manufacturing and Regulatory Success

Gregory Russotti is the Chief Technology and Manufacturing Officer at Century Therapeutics, a company developing iPSC-derived, allogeneic immune cell therapy products for hematology/oncology ...
Frontiers

Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice

Introduction: Shexiang Tongxin Dropping Pills (STDP), a traditional Chinese medicine (TCM), is clinically used for cardiovascular diseases like myocardial ischemia. Myocardial ischemia-reperfusion ...
The American Journal of Managed Care

Multicancer Detection Assays Remain Largely Elusive for Early-Stage Disease Detection

Multicancer early detection (MCED) assays use circulating tumor DNA, methylation patterns, RNA, and protein biomarkers to detect multiple cancer types early, potentially revolutionizing cancer ...
ascopubs.org

Clinical performance of Signatera Genome assay in a cohort of patients (pts) with solid tumors.

A minimal comprehensive somatic panel to aid clinical decision making in a low cost setting. Landscape of genomic alterations in genes implicated in the regulation of hypoxia inducible factor (HIF) ...
GEN

Single-Assay Evaluation of AAV Capsid Quality: Novel Digital PCR Approaches Advance Gene Therapy Research and Production

Gene therapy (introducing genetic material into living cells to fix, replace, enhance, or block a faulty gene) is rapidly gaining traction as a strategy for the treatment of genetic diseases. The ...
Frontiers

Cellular effects of splenectomy on liver regeneration after 70% resection

Introduction: Mammalian liver regeneration is a complex process, the regulation of which involves many mechanisms. The immune system has a pronounced influence on the course of reparative processes in ...
Business Wire

Inocras Unveils New MRDVision™ Data, Demonstrating Industry-leading Sensitivity in Head-to-Head Clinical Study Against Leading MRD NGS Assay

SAN DIEGO--(BUSINESS WIRE)--Today, Inocras, a leader in whole genome sequencing (WGS) and bioinformatics, announced MRDVision, its solution for minimal residual disease (MRD) detection, validated to ...