Cleveland Browns All-Pro edge rusher Myles Garrett is on the doorstep of NFL history. His 21.5 sacks lead the league by a ...

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.

All three members of ESPN are picking the 49ers as well. ESPN's Football Power Index simulation model has the 49ers winning ...

The Indianapolis Colts and San Francisco 49ers face off in "Monday Night Football" this week. Check out how to watch on ESPN now.

Kyle Shanahan challenged Jordan Watkins to be "better than the guys in front of him" to earn snaps. The San Francisco 49ers' ...

The 49ers running game has been up and down, but they could have an advantage against a very solid Colts run defense ...

It wasn't just the Seahawks celebrating Thursday's night win. The 49ers now have a path to the NFC West title, too.

In the 49ers’ last matchup against the Tennessee Titans, Pearsall injured his ankle on the very first play from scrimmage but ...

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster ...

A lot of the 49ers' biggest contributors weren't on the team last year. Heck, some of them weren't even on the team in Week 1 ...

USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

She also reveals if it's more stressful to watch Fred play out on the field or have him up in the suite with her ...