The SportsLine Projection Model has revealed its Clemson Tigers vs. Louisville Cardinals picks for Friday's ACC matchup

Clemson offensive lineman Brayden Jacobs suffered a season-ending injury after the Louisville game, per Dabo Swinney.

Coach Dabo Swinney announced Sunday that true freshman offensive lineman Brayden Jacobs has a foot injury and will miss the rest of the 2025 season for the Tigers. Clemson (5-5) ends the regular season with games vs. Furman (home) and South Carolina (away) and will likely play in a bowl game, too.

Clemson looks to make a bowl game and spoil Louisville's CFP hopes with a win in Week 12. Here's what to know about the game and a prediction.

Six teams in the AP Top 25 lost in Week 12, including two from the ACC and two from the SEC. Several others escaped upsets.

Clemson had lost 2 straight games with a bye week sandwiched in, so when it defeated the 1.5-point underdog Florida State Seminoles 24-10 (Under 57) last Saturday the victory marked the Tigers' first since Oct. 18. Clemson's 5 losses mark its most since coach Dabo Swinney ' s first season (2009).

Dabo Swinney is in the middle of his worst season as Clemson football coach as the Tigers head into their road game with Louisville in Week 12.

Leading up to the matchup against Clemson, Florida State released its uniform combination for the game. The Seminoles will be wearing their sixth different uniform combination of the season. It'll be traditional road uniforms - gold helmets, white jerseys, and gold pants - for the first time this year.