Age-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease. Comprehensive atlases of the BEC transcriptome have become available, but results from ...

This approach can now be used to tailor the transport system to a wide range of peptides with unnatural amino acids. For example, the team was even able to introduce bulky or negatively charged amino ...

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs and signalling molecules that regulate developmental and homeostatic pathways. Cilia are therefore ...

Malaria kills over 600,000 people a year, and as the climate warms, the potential range of the disease is growing. While some drugs can effectively prevent and treat malaria, resistance to those drugs ...

Researchers at the University of Adelaide have discovered that a protein which mediates the transport of alkali metal ions, such as potassium, and halide ions across plant membranes acts similarly to ...

This illustration shows how the membrane trafficking protein VAMP72 gradually changed during plant evolution to give rise to VAMP727, which functions in transporting storage proteins to vacuoles. The ...

A research team has revealed the molecular steps that led to the emergence of this plant-specific vacuolar transport system. Their work shows that the acquisition of this pathway was driven by the ...