How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

For the first time, scientists at Albert Einstein College of Medicine have developed a technology allowing them to "see" single molecules of messenger RNA as they are translated into proteins in ...

Double-stranded RNA (dsRNA) is a well-recognized byproduct of in vitro transcription that poses significant challenges for the use of synthetic mRNA in research and therapeutic applications. Even ...

Our study progresses from the rational design of polyplex micelles to the mechanistic elucidation of mRNA degradation, revealing RNase infiltration—rather than carrier dissociation—as the principal ...

Imagine a cancer treatment that precisely targets malignant cells, leaving healthy ones untouched. Consider, also, a cancer treatment that corrects abnormal protein synthesis to produce healthy ...

AI-driven tumor immunity mapping could improve mRNA vaccine design, delivery, and personalization in oncology. Read more.

Subtle differences in an mRNA sequence enables a ribosome to produce more or less of a certain protein. A new AI model called RiboNN predicts which sequences will be most efficiently produced and ...

The COVID pandemic ushered mRNA vaccines into the spotlight, and the technology has even greater potential. Here’s what to ...

Researchers have developed a new lipid nanoparticle design that directs mRNA to the pancreas by exploiting the organ’s own ...