The gene p53 acts as a tumor suppressor and is often called the guardian of the genome. This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading to ...

Geneticists have sought to understand the impact of genetic mutations, and what drives and maintains changes in DNA. Researchers have now reconstructed the evolution of a set of genes, and the ...

Genomes are key to unlocking life's evolutionary history. The presence and absence of certain genetic sequences and mutations ...

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like ...

Scientists have created a new technique that can assess how mutations in the genome influence the packaging of DNA in cells. The genome is massive, and has to be carefully wrapped around proteins so ...

The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ But when p53 mutates, it can flip from protector to promoter of cancer. Gene p53 is mutated in about 50% of ...

The DNA mutations that drive evolution are generally thought to be fairly random, but a new study suggests there’s some order to the chaos. Comparing the genomes of hundreds of plants grown in a lab, ...

A team of Northwestern investigators has discovered novel molecular underpinnings of a common oncogenic mutation in cancer, ...

A new long-read sequencing technique has helped researchers investigate how DNA mutations arise in a variety of contexts. A collaboration of researchers led by NYU Langone Health and NYU Grossman ...

SALT LAKE CITY—Cells with a mutation in the gene called K-Ras—found in close to 30 percent of all cancers, but mostly those with worst prognosis, such as pancreatic cancer, colon cancer, and lung ...

Although previously thought to be neutral, research in yeast suggests that synonymous point mutations may have strongly nonneutral effects. A group of researchers from the University of Michigan (MI, ...