EORTCMYC is a highly desirable oncogenic target that historically eluded drug huntersSmall molecules that inhibit the ...

Signals that control the fine balance between cell death and cell survival are altered during tumorigenesis. Understanding the mechanisms by which this balance is perturbed, leading to excessive cell ...

The Myc protein plays a key role in the development of several tumor types and its inhibition could therefore prove an effective therapy against many different cancers. Previous studies successfully ...

Preliminary results from a phase I clinical trial show that the first in class MYC inhibitor Omomyc (OMO-103) has few side effects, is tolerable, and stabilizes disease in some patients. Developed ...

Sperm – in theory, you only need one good one to get the job done. Nevertheless, the average pair of human testicles is estimated to crank out about a trillion of these little cells over a lifetime, ...

The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the ...

Beijing DP Technology Co. Ltd. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently bonded to a Myc proto-oncogene protein ...

Race Oncology has achieved a breakthrough with its lead candidate RC220, uncovering the primary mechanism of action of its ...