Learn why cytotoxicity test failures are common in medical devices and discover systematic approaches to identify root causes ...

The detrimental effects caused by substances or environmental changes on cell health are described as cytotoxicity. When cells are exposed to a cytotoxic stimulus, their metabolic activity may be ...

ADCs combine antibodies with drug payloads for targeted therapy, but complex manufacturing requires monitoring CQAs across multiple entities.

Cellular Metabolism Live-Cell Assays for Research and Drug Discovery Cellular energy production depends on mitochondrial integrity and function. Mitochondrial dysfunction has been shown to alter the ...

This article and associated images are based on a poster originally authored by Denise Sullivan, Zhong Yu, Benjamin Streeter, Stacie Chvatal and Daniel Millard and presented at ELRIG Drug Discovery ...

Thirty-four consecutive patients were identified initially, with successful completion of the assay before surgery in those 17 patients who underwent full treatment. An in vitro cytotoxic assay of ...