The anticipation, nerves and excitement of a new college football campaign are gone. Now comes the hard part: the in-season grind.

College football returned with a wild Week 1 of the 2025 season. The Week 2 slate doesn’t have as many high-profile games, but we’ll make some predictions nonetheless. Each week, I’ll be sharing against the spread and over/under picks. We’ll cover the biggest games of the weekend while sprinkling in a few under-the-radar matchups, too.

Newsweek Sports Betting Editor Tyler Everett makes his early picks against the spread for the top Week 2 matchups in college football.