Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Axonal degeneration and neuroinflammation are increasingly recognised as pivotal processes in the pathogenesis of neurodegenerative diseases. Axonal degeneration refers to the progressive ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent studies suggest ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Carnegie Mellon University's Jessica Zhang and Angran Li have developed a new way to model material transport regulation in neurons, focusing on the "traffic jams" that occur in these neural pathways.

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death. A ...

Axons connect neurons across great distances in the nervous system, and this distance is a fundamental vulnerability for neurons. Maintenance of functional connectivity requires robust mechanisms for ...

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...

Dysfunctional presenilin 1, infamous for misprocessing the amyloid precursor protein in familial Alzheimer’s disease, isn’t a one-trick pony. PS1 variants also weaken lysosomes, slow endosomal ...