Keeping the genetic information stored in genomic DNA intact during the cell division cycle is crucial for almost all lifeforms. Extensive DNA damage invariably causes various adverse genomic ...

A new study led by NYU Langone Health researchers found that cancer cells are better able to resist treatments when they have an abnormal number of chromosomes, which are DNA strands wound up in ...

The current study shows that cells with additional chromosomes have an altered mitochondrial structure and function. The reason: mitochondrial precursor proteins are sequestered in p62-positive ...

Using this method, they found that a combination of failures—from the partial loss of an essential protein to weakened connections between chromosomes—can cause errors that increase with maternal age.

A tension-sensitive "fail safe" protein helps make sure that when our cells divide the two resulting cells inherit the normal number of chromosomes, researchers from the University of Washington and ...

Aneuploidy (the presence of an abnormal number of chromosomes) in embryos is a major cause of impaired embryo development, leading to conditions such as Down syndrome, as well as to pregnancy loss.

More than two-thirds of early miscarriages seem to be due to abnormal chromosomes, the packages of DNA within all our cells, in the embryo or fetus. The remaining third are probably also largely due ...

DLGAP5 is proposed as a causal gene related to oocyte meiosis disorder for the first time. It expanded the current spectrum of pathogenic genes responsible for the phenotype of oocyte maturation and ...

Human egg cells are often prone to chromosomal errors. As women age, the error rate increases sharply — and can contribute to infertility, pregnancy loss, and ...