San Francisco 49ers tight end George Kittle has been thoroughly impressed by what he's seen from defensive lineman Alfred Collins so far this year.

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) throws the ball while Arizona Cardinals defensive lineman Walter Nolen III (97) defends in the first half at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images / Matt Kartozian-Imagn Images

George Kittle called the 49ers’ now-healthy attack “very lethal” after Brock Purdy’s impressive injury return.

Fresh off a convincing win on the road against the Atlanta Falcons, the 6-5 Carolina Panthers are headed to California to take on the San Francisco 49ers in their first primetime game since Bryce Young’s rookie season.

The 49ers head to State Farm Stadium to face the Arizona Cardinals with Brock Purdy back under center. Purdy was cleared off the injury report and is starting after missing six games with a turf-toe variant.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

The San Francisco 49ers entered Sunday in Week 11 with a healthy team, at least in terms of players on the roster. Quarterback Brock Purdy and receiver Ricky Pearsall would return after missing several games.

ESPN’s FPI projections have the 49ers finishing with 11 wins, with a 90 percent chance of making the postseason. There’s still a 19 percent chance to win the division, but that looks like a race for the Rams (62.3 percent projections to win the NFC West) to lose.