Pregame analysis and predictions of the Michigan State Spartans vs. Iowa Hawkeyes NCAAF game to be played on November 22, 2025 on ESPN.

Michigan State football has opened as a massive underdog for next week's road game at Iowa. The Spartans are listed as a 15 1/2-point underdog for next week's game at Iowa, according to FanDuel. The over/under is set at 43 1/2 points.

Michigan State hits the road in the penultimate game of the regular season to face Iowa (6-4, 4-3) Saturday afternoon where it opens as 16.5-point underdogs to the Hawkeyes, according to FanDuel odds on Sunday. Iowa just dropped out of the AP Top 25 after suffering back-to-back losses to No. 6 Oregon and No. 16 USC. Both losses were by one score.

The Big Ten did big things at college wrestling’s National Duals Invitational Saturday and Sunday in Tulsa as Ohio State thumped Iowa 27-12 to win the $200,000 pot while Nebraska placed fourth, Minnesota fifth and Illinois seventh.

Nebraska could have enjoyed an edge against Penn State next Saturday, but that advantage was wiped out in the second half of the Nittany Lions’ win at Michigan

Penn State finally snapped its six-game losing streak with a controlled 28-10 win at Michigan State on Saturday at Spartan Stadium, claiming the Land Grant Trophy for the third consecutive year for the first time since 2004-06.